A Very Early Rehabilitation Trial for Stroke (AVERT)
2008; Lippincott Williams & Wilkins; Volume: 39; Issue: 2 Linguagem: Inglês
10.1161/strokeaha.107.492363
ISSN1524-4628
AutoresJulie Bernhardt, Helen M. Dewey, Amanda G. Thrift, Janice Collier, Geoffrey A. Donnan,
Tópico(s)Botulinum Toxin and Related Neurological Disorders
ResumoVery early rehabilitation, with an emphasis on mobilization, may contribute to improved outcomes after stroke. We hypothesized that a very early rehabilitation protocol would be safe and feasible.We performed a randomized, controlled trial with blinded outcome assessment. Patients at 7. There was no significant difference in the number of deaths between groups (SC, 3 of 33; VEM, 8 of 38; P=0.20). Almost all deaths occurred in patients with severe stroke. Secondary safety outcomes were similar between groups. The intervention protocol was successfully delivered, achieving VEM dose targets (double SC, P=0.003) and faster time to first mobilization (P<0.001).VEM of patients within 24 hours of acute stroke appears safe and feasible. Intervention efficacy and cost-effectiveness are currently being tested in a large randomized, controlled trial.
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