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Aberrant galactosylation of IgA1 is involved in the genetic susceptibility of Chinese patients with IgA nephropathy

2009; Oxford University Press; Volume: 24; Issue: 11 Linguagem: Inglês

10.1093/ndt/gfp294

1460-2385

Xiaojie Lin, Jie Ding, Li Zhu, S. Shi, Liping Jiang, Mingming Zhao, H. Zhang,

Platelet Disorders and Treatments

Background. Immunoglobulin A nephropathy (IgAN) is associated with genetic and environmental factors, and undergalactosylation of IgA1 in the serum is considered to be a contributor to pathogenesis of IgAN. The present study was conducted to detect the galactose- (Gal) deficient IgA1 level in Chinese IgAN patients and their family members.