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Synthesis, characterization and biocompatibility of PEGA resins

1995; Wiley; Volume: 1; Issue: 1 Linguagem: Inglês

10.1002/psc.310010106

1099-1387

France‐Isabelle Auzanneau, Morten Meldal, Klaus Bock,

Supramolecular Self-Assembly in Materials

Abstract Three types of beaded polyethylene glycol polyacrylamide copolymers (PEGA) with a high content of polyethylene glycol (PEG) were synthesized by inverse suspension polymerization and characterized for peptide synthesis and with respect to their physical properties. Several peptides of high purity have been synthesized on the resin. The properties which were determined were loading of amino group, swelling, bead size distribution, porosity, flexibility and compatibility with active biomolecules. A loading of 0.35 mmol/g has been obtained and the swelling was excellent in solvents of various polarities ranging from water to dichloromethane. The 13 C‐NMR T 1 ‐relaxation times of a resin containing a peptide were determined in DMSO‐d 6 and the resin was found to exhibit a behaviour similar to the components in free solution.