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Novos conceitos sobre a fisiologia da hemostasia

2012; UNIVERSIDADE VALE DO RIO VERDE; Volume: 10; Issue: 1 Linguagem: Inglês

10.5892/ruvrv.2012.101.218233

2236-5362

Evandra Strazza Rodrigues,

Blood properties and coagulation

Haemostasis comprises a series of reactions that preventing blood loss, restore vascular integrity and maintains physiological conditions that preserve life. Understanding of hemostatic system includes the acknowledgement of complex mechanism controlled by the vascular endothelium, platelets, the coagulation pathway and fibrinolysis. Recent advancements in the comprehension of concept of the coagulation cascade, by clinical and experimental observations demonstrated that the classical cascade model doesn't completely reflect the process of hemostasis in vivo . Then, this article discusses several hemostatic and fibrinolic components, the endothelium, cell- derived microparticles and platelets. Next, we described the classical cascade model and the changes that occurred in the understanding of physiologic processes of coagulation in order to be proposed the actual model of coagulation cascade based on the cell surfaces.