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BIBTEX RIS

Antibody isotype responses in Balb/c mice immunized with the cytoplasmic repetitive antigen and flagellar repetitive antigen of Trypanosoma cruzi

2003; Instituto Oswaldo Cruz, Ministério da Saúde; Volume: 98; Issue: 6 Linguagem: Inglês

10.1590/s0074-02762003000600019

ISSN

1678-8060

Autores

Valéria RA Pereira, Virgínia Maria Barros de Lorena, Alinne Fernanda Amaral Verçosa, Edmilson D. Silva, Antonio GP Ferreira, Ulísses Ramos Montarroyos, Ana Paula Galvão da Silva, Yara M. Gomes,

Tópico(s)

Toxin Mechanisms and Immunotoxins

Resumo

In the present report we analyzed the levels of IgG1, IgG2a, IgG2b and IgG3 isotypes from Balb/c mice immunized with cytoplasmic repetitive antigen (CRA), and flagelar repetitive antigen (FRA) of Trypanosoma cruzi. The immunization was done by subcutaneous route three times (20 days apart) and the analysis was performed 14 days after each treatment. CRA-immunized mice produced high levels of all IgG isotypes, mainly IgG3 and IgG1. FRA-immunization elicited only high levels of IgG1.

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