Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models
2013; American Association for Cancer Research; Volume: 73; Issue: 17 Linguagem: Inglês
10.1158/0008-5472.can-13-1069
ISSN1538-7445
AutoresDespina Siolas, Gregory J. Hannon,
Tópico(s)3D Printing in Biomedical Research
ResumoTumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalized medicine for patients with cancer. In addition, these models can be used to study metastasis and tumor genetic evolution. This review examines the development, challenges, and broad use of these attractive preclinical models.
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