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BIBTEX RIS

Cutting Edge: Immediate RANTES Secretion by Resting Memory CD8 T Cells Following Antigenic Stimulation

2003; American Association of Immunologists; Volume: 170; Issue: 4 Linguagem: Inglês

10.4049/jimmunol.170.4.1615

ISSN

1550-6606

Autores

Thierry Walzer, Antoine Marçais, Frédéric Saltel, Chantal Bella, Pierre Jurdic, Jacqueline Marvel,

Tópico(s)

Immune Cell Function and Interaction

Resumo

Abstract The efficiency of CD8 memory response relies partially on the modification of cellular functional capacities. To identify effector functions that can be modified following priming, we have compared the chemokines produced by naive and memory CD8 T cells. Our results show that in contrast to naive cells, resting memory CD8 T cells contain high levels of RANTES mRNA. As a result, they have the capacity to rapidly secrete RANTES upon ex vivo antigenic stimulation. In contrast to that of IFN-γ, RANTES secretion is mainly due to the translation of the pre-existing mRNA.

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