Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Severe Chronic Allergic (and Related) Diseases: A Uniform Approach – A MeDALL – GA²LEN – ARIA Position Paper

2012; Karger Publishers; Volume: 158; Issue: 3 Linguagem: Inglês

10.1159/000332924

1423-0097

Jean Bousquet, J. M. Antó, Pascal Demoly, Holger J. Schünemann, Alkis Togias, Mübeccel Akdiş, Charles Auffray, Claus Bachert, T. Bieber, Philippe‐Jean Bousquet, K.‐H. Carlsen, Thomas B. Casale, Álvaro A. Cruz, Thomas Keil, Karin C. Lødrup Carlsen, Marcus Maurer, Ken Ohta, Nikolaos G. Papadopoulos, Miguel Román-Rodríguez, Bolesław Samoliński, Ioana Agache, A.C.F. Andrianarisoa, C. S. Ang, I. Annesi‐Maesano, Ferrán Ballester, C Baena-Cagnani, Xavier Basagaña, E. D. Bateman, Elisabeth H. Bel, Anna Bedbrook, Bianca Beghè, M. Béji, A. Ben Kheder, Marta Benet, Kazi Saifuddin Bennoor, Karl‐Christian Bergmann, F. Berrissoul, Carsten Bindslev‐Jensen, Eugene R. Bleecker, С. Бонини, Attilio Boner, LP Boulet, Christopher E. Brightling, Jan Brožek, A. Bush, William W. Busse, Paulo Augusto Moreira Camargos, Giorgio Walter Canonica, Warner Carr, Alfredo Cesario, Y. Z. Chen, Anca‐Mirela Chiriac, David Costa, Linda Cox, Adnan Ćustović, Ronald Dahl, U. Darsow, T. Didi, William K. Dolen, H. Douagui, R. Dubakiene, A. El-Meziane, João Fonseca, Wytske J. Fokkens, Eleni Fthenou, A. Gamkrelidze, Judith García‐Aymerich, Roy Gerth van Wijk, Elena Gimeno‐Santos, Stefano Guerra, Tari Haahtela, Majed Haddad, Peter W. Hellings, B. Hellquist-Dahl, Cynthia Hohmann, Peter Howarth, J. O’. B. Hourihane, Marc Humbert, Bénédicte Jacquemin, J. Just, Ömer Kalaycı, Michael Kaliner, F. Kauffmann, Marjan Kerkhof, Georges Khayat, B. Koffi N’Goran, Manolis Kogevinas, Gerard H. Koppelman, M. L. Kowalski, Inger Kull, Piotr Kuna, Désirée Larenas‐Linnemann, Iris Lavi, L. T. T. Le, Phil Lieberman, Brian J. Lipworth, Bassam Mahboub, Mika J. Mäkelä, F Martín, F. D. Martinez, Gailen D. Marshall, Ángel Mazón, E. Melén, Eli O. Meltzer, Florin Mihălţan, Yousser Mohammad, Ali Mohammadi, Isabelle Momas, Mário Morais‐Almeida, Joaquim Mullol, Antonella Muraro, Robert M. Naclerio, S. Nafti, Leyla S. Namazova-Baranova, Martijn C. Nawijn, T. D. Nyembue, Sam Oddie, Robyn E. O’Hehir, Yoshitaka Okamoto, Marco Orrù, Cevdet Özdemir, G. S. Ouedraogo, S. Palkonen, Petr Panzner, Giovanni Passalacqua, R. Pawankar, B. Pigearias, Isabelle Pin, Mariona Pinart, Christophe Pison, Todor A. Popov, Daniela Porta, Dirkje S. Postma, David Price, Klaus F. Rabe, J. Ratomaharo, Sakari Reitamo, D. Rezagui, Johannes Ring, Richard Roberts, Josep Roca, Barbara Rogala, Antonino Romano, J. Rosado‐Pinto, Dermot Ryan, Mario Sánchez‐Borges, G. K. Scadding, Aziz Sheikh, F. Estelle R. Simons, Valérie Siroux, Peter Schmid-Grendelmeier, H. A. Smit, Talant Sooronbaev, Renato T. Stein, Peter J. Sterk, Jordi Sunyer, Ingrid Terreehorst, Е. Тоскала, Y. Tremblay, Rudolf Valenta, Dominique Valeyre, Olivier Vandenplas, Chris van Weel, Maria Vassilaki, Raphaëlle Varraso, Giovanni Viegi, De Yun Wang, Magnus Wickman, David M. Williams, Stefan Wöhrl, John Wright, Arzu Yorgancıoğlu, Osman Yusuf, Heather J. Zar, M. E. Zernotti, Mihaela Zidarn, N. Zhong, Torsten Zuberbier,

Respiratory and Cough-Related Research

Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.