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Review of the Effect of Highly Active Antiretroviral Therapy on Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus and HCV Coinfection

2002; Oxford University Press; Volume: 35; Issue: 7 Linguagem: Inglês

10.1086/342388

1537-6591

Curtis Cooper, D. William Cameron,

HIV/AIDS drug development and treatment

The effect of anti-human immunodeficiency virus (HIV) treatment on hepatitis C virus (HCV) RNA levels in HIV-HCV-coinfected persons is uncertain. Although it is commonly believed that, with the initiation of HIV treatment, there may be an initial increase followed by a gradual decrease of HCV RNA levels to lower than those at pretreatment, the published studies evaluating this are of small and heterogeneous populations, are limited in follow-up, and have conflicting results. A prospective clinical trial of sufficient size and duration may help clarify this issue. This may be clinically relevant, because lower HCV RNA levels are a predictive factor for favorable response to HCV antiviral therapy.