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BIBTEX RIS

Finding Reaction Pathways for Multicomponent Reactions: The Passerini Reaction is a Four‐Component Reaction

2010; Wiley; Volume: 50; Issue: 3 Linguagem: Inglês

10.1002/anie.201005336

ISSN

1521-3773

Autores

Satoshi Maeda, Shinsuke Komagawa, Masanobu Uchiyama, Keiji Morokuma,

Tópico(s)

Inorganic and Organometallic Chemistry

Resumo

Route finder: The Passerini three-component reaction of a carboxylic acid, an aldehyde (or ketone), and an isocyanide to give an α-acyloxycarboxamide actually follows a four-component mechanism involving an additional molecule of carboxylic acid (see scheme). The discovery was made by applying a new “reaction route explorer” to the simplest Passerini reaction (HCOOH+HCHO+CH3NC).

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