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Lithium Carbonate and Sleep in Affective Disorders

1974; American Medical Association; Volume: 30; Issue: 1 Linguagem: Inglês

10.1001/archpsyc.1974.01760070061009

1538-3636

David J. Kupfer,

EEG and Brain-Computer Interfaces

The effect of lithium carbonate on electroencephalographic sleep parameters was evaluated in six patients with affective disorders. Confirming earlier results, we report significant reductions in rapideye-movement (REM) percent and phasic-REM activity during the drug period. Doubling of delta-sleep time occurred during lithium administration, and a negative correlation between REM percent and delta percent was found; there was no immediate REM compensation in the postdrug period. We propose a model for REM suppression based on REM-cycle length and the presence or absence of REM rebound.