Fibrin Clot Visualized by Optical Coherence Tomography
2008; Lippincott Williams & Wilkins; Volume: 118; Issue: 4 Linguagem: Inglês
10.1161/circulationaha.107.749564
ISSN1524-4539
AutoresTeruyoshi Kume, Hiroyuki Okura, Takahiro Kawamoto, Takashi Akasaka, Eiji Toyota, Nozomi Watanabe, Yoji Neishi, Yoshito Sadahira, Kiyoshi Yoshida,
Tópico(s)Cerebrovascular and Carotid Artery Diseases
ResumoHomeCirculationVol. 118, No. 4Fibrin Clot Visualized by Optical Coherence Tomography Free AccessReview ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessReview ArticlePDF/EPUBFibrin Clot Visualized by Optical Coherence Tomography Teruyoshi Kume, MD, Hiroyuki Okura, MD, Takahiro Kawamoto, MD, Takashi Akasaka, MD, Eiji Toyota, MD, Nozomi Watanabe, MD, Yoji Neishi, MD, Yoshito Sadahira, MD and Kiyoshi Yoshida, MD Teruyoshi KumeTeruyoshi Kume From the Department of Cardiology (T. Kume, H.O., T. Kawamoto, E.T., N.W., Y.N., K.Y.) and Department of Pathology (Y.S.), Kawasaki Medical School, Kurashiki, Japan; and Department of Cardiology, Wakayama Medical University, Wakayama, Japan (T.A.). , Hiroyuki OkuraHiroyuki Okura From the Department of Cardiology (T. Kume, H.O., T. Kawamoto, E.T., N.W., Y.N., K.Y.) and Department of Pathology (Y.S.), Kawasaki Medical School, Kurashiki, Japan; and Department of Cardiology, Wakayama Medical University, Wakayama, Japan (T.A.). , Takahiro KawamotoTakahiro Kawamoto From the Department of Cardiology (T. Kume, H.O., T. Kawamoto, E.T., N.W., Y.N., K.Y.) and Department of Pathology (Y.S.), Kawasaki Medical School, Kurashiki, Japan; and Department of Cardiology, Wakayama Medical University, Wakayama, Japan (T.A.). , Takashi AkasakaTakashi Akasaka From the Department of Cardiology (T. Kume, H.O., T. Kawamoto, E.T., N.W., Y.N., K.Y.) and Department of Pathology (Y.S.), Kawasaki Medical School, Kurashiki, Japan; and Department of Cardiology, Wakayama Medical University, Wakayama, Japan (T.A.). , Eiji ToyotaEiji Toyota From the Department of Cardiology (T. Kume, H.O., T. Kawamoto, E.T., N.W., Y.N., K.Y.) and Department of Pathology (Y.S.), Kawasaki Medical School, Kurashiki, Japan; and Department of Cardiology, Wakayama Medical University, Wakayama, Japan (T.A.). , Nozomi WatanabeNozomi Watanabe From the Department of Cardiology (T. Kume, H.O., T. Kawamoto, E.T., N.W., Y.N., K.Y.) and Department of Pathology (Y.S.), Kawasaki Medical School, Kurashiki, Japan; and Department of Cardiology, Wakayama Medical University, Wakayama, Japan (T.A.). , Yoji NeishiYoji Neishi From the Department of Cardiology (T. Kume, H.O., T. Kawamoto, E.T., N.W., Y.N., K.Y.) and Department of Pathology (Y.S.), Kawasaki Medical School, Kurashiki, Japan; and Department of Cardiology, Wakayama Medical University, Wakayama, Japan (T.A.). , Yoshito SadahiraYoshito Sadahira From the Department of Cardiology (T. Kume, H.O., T. Kawamoto, E.T., N.W., Y.N., K.Y.) and Department of Pathology (Y.S.), Kawasaki Medical School, Kurashiki, Japan; and Department of Cardiology, Wakayama Medical University, Wakayama, Japan (T.A.). and Kiyoshi YoshidaKiyoshi Yoshida From the Department of Cardiology (T. Kume, H.O., T. Kawamoto, E.T., N.W., Y.N., K.Y.) and Department of Pathology (Y.S.), Kawasaki Medical School, Kurashiki, Japan; and Department of Cardiology, Wakayama Medical University, Wakayama, Japan (T.A.). Originally published22 Jul 2008https://doi.org/10.1161/CIRCULATIONAHA.107.749564Circulation. 2008;118:426–427Optical coherence tomography (OCT) is a recently developed optical imaging technique that provides high-resolution (≈10 to 20 μm) cross-sectional images of vessels.1 It has been reported that OCT images of white and red thrombus were characterized as backscattering protrusions in the coronary lumen.2 However, OCT characteristics of fibrin clot composed of fibrin material and few blood cells have not been described.The coronary arteries of a 75-year-old man who died from acute myocardial infarction were obtained at autopsy. Histopathological examination showed fibrin clot composed of fibrin material and few blood cells in the coronary artery (Figure, A and B). Before proceeding with a standard histopathological examination, we visualized the coronary artery using OCT. OCT characteristics of fibrin clot, a signal-rich structure without backscattering, were obviously different from white or red thrombus that were characterized as a signal-rich structure with backscattering (Figure, C). Download figureDownload PowerPointFigure. Correlation between optical OCT images (C, F, and I) and histological examinations of human coronary fibrin clot (A and B), red thrombus (D and E), and white thrombus (G and H) obtained at autopsy. A and B, Fibrin clot was composed of fibrin material and few blood cells. *Fibrin clot, hematoxylin and eosin stain. D and E, Red thrombus (RT) consisted mainly of red blood cells (hematoxylin and eosin stain). H and I, White thrombus (WT) consisted mainly of platelets, fibrin, and white blood celld (hematoxylin and eosin stain). C, OCT image of fibrin clot was characterized as a signal-rich structure without backscattering. *Fibrin clot. F and I. OCT images of red and white thrombi were visualized as a signal-rich structure with backscattering (RT indicates red thrombus; WT; white thrombus).Although drug-eluting stents have reduced rates of restenosis and late lumen loss compared with bare-metal stents, thrombosis has emerged as a major concern. In addition, delayed arterial healing, as evidenced by persistence of fibrin clot after DES implantation, has been demonstrated. Although OCT might be useful for monitoring structural changes after DES implantation, it might be difficult, using OCT, to discriminate fibrin clot from minimal neointimal formation after DES implantation.DisclosuresNone.FootnotesCorrespondence to Hiroyuki Okura, MD, Department of Cardiology, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701–0192, Japan. E-mail [email protected]References1 Kume T, Akasaka T, Kawamoto T, Watanabe N, Toyota E, Neishi N, Sukmawan R, Sadahira Y, Yoshida K. 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July 22, 2008Vol 118, Issue 4 Advertisement Article InformationMetrics https://doi.org/10.1161/CIRCULATIONAHA.107.749564PMID: 18645069 Originally publishedJuly 22, 2008 PDF download Advertisement SubjectsImagingThrombosis
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