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Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects

2010; Royal Society of Chemistry; Volume: 34; Issue: 5 Linguagem: Inglês

10.1039/c0nj00041h

1369-9261

Jacek Jemielity, Joanna Kowalska, Anna M. Rydzik, Edward Darżynkiewicz,

DNA and Nucleic Acid Chemistry

The cap structure was discovered at the 5′-end of the eukaryotic mRNA over three and a half decades ago. Since then, hundreds of chemically modified cap analogs have been synthesized and applied in numerous studies on the elucidation of cap-related physiological processes in the cell, and became important members of the biophosphate family. In this Perspective, we present recent developments in the synthesis of cap analogs modified within 5′,5′-triphosphate bridges and their utility for interdisciplinary studies on cap-dependent processes in gene expression and its regulation, as well as biotechnological applications and perspectives in medicine.