An overview of six clinical trials of aspirin in coronary heart disease
1987; Wiley; Volume: 6; Issue: 3 Linguagem: Inglês
10.1002/sim.4780060310
ISSN1097-0258
Autores Tópico(s)Antiplatelet Therapy and Cardiovascular Diseases
ResumoAbstract Data from six randomized, placebo‐controlled clinical trials of aspirin, involving a total of 10,703 post‐myocardial infarction patients, have been compared and combined. An apparent heterogeneity of findings among the six trials with respect to all‐cause mortality is noted (P = 0.08). The reasons for this heterogeneity are explored. Two common methods of combining the results of several trials – the logrank and the log odds ratio methods – yield two‐sided P ‐values of 0.112 and 0.110, respectively, for the aspirin‐placebo effect on all‐cause mortality. Alternative statistical methods of combining the results of the six trials give two‐sided P ‐values ranging from 0.017 to 0.487.
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