Produção Nacional
Revisado por pares
Study of lipid metabolism-related genes as candidate genes of sexual precocity in Nellore cattle
2015; Research Foundation of Ribeirão Preto; Volume: 14; Issue: 1 Linguagem: Inglês
10.4238/2015.january.16.7
ISSN1676-5680
AutoresMarina Mortati Dias Barbero, Fábio Ricardo Pablos de Souza, Luciana Takada, Fabieli Loise Braga Feitosa, Raphael Bermal Costa, Iara Del Pilar Solar Diaz, Diércles F. Cardoso, Rafael Lara Tonussi, Fernando Baldi, Lúcia Galvão de Albuquerque, Henrique Nunes de Oliveira,
Tópico(s)Reproductive Physiology in Livestock
ResumoThe objective of this study was to identify associations between known polymorphisms in genes related to adipose tissue and sexual precocity in Nellore cattle.A total of 1689 precocious and nonprecocious heifers belonging to farms participating in Conexão Delta G breeding program were studied.SNPs from the Illumina High-Density Bovine SNP BeadChip were used.This chip contains 777,000 SNPs located within the region of the candidate genes at a distance of up to 5 kb, considering that linkage disequilibrium (LD) exists at this distance.Linear models were used for statistical analysis.The fastPHASE and GenomeStudio programs were used for haplotype reconstruction and LD analysis based on r 2 statistics.Fifty-seven candidate genes and 443 SNPs were analyzed: among the latter, 370 SNPs formed 83 haplotypes, while the remaining SNPs were studied separately.Statistical analysis showed that only three haplotypes, one haplotype consisting of two SNPs located in the FABP4 gene and two haplotypes consisting of four and ©FUNPEC-RP www.funpecrp.com.br
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