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BIBTEX RIS

A β‐Carboline‐1‐one Mimic of the Anticancer Amaryllidaceae Constituent Pancratistatin: Synthesis and Biological Evaluation

2004; Wiley; Volume: 43; Issue: 40 Linguagem: Inglês

10.1002/anie.200460218

ISSN

1521-3773

Autores

Uwe Rinner, Tomáš Hudlický, Heather Gordon, George R. Pettit,

Tópico(s)

Psychedelics and Drug Studies

Resumo

New drug design possibilities are suggested by the results of a biological evaluation of the indole derivative 1 of pancratistatin, a known anticancer agent, in a panel of cancer cell lines. Enzymatic dihydroxylation was one of the key steps in the short, enantioselective synthesis of 1.

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