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Is depression associated with microvascular disease in patients with type 2 diabetes?

2007; Wiley; Volume: 25; Issue: 11 Linguagem: Inglês

10.1002/da.20427

1520-6394

Thanh T. Nguyen, Tien Yin Wong, Amirul Islam, Larry D. Hubbard, Jacqueline Miller, Ebrahim Haroon, Christine Darwin, Barbara Esser, Anand Kumar,

Retinal Diseases and Treatments

Depression and AnxietyVolume 25, Issue 11 p. E158-E162 Brief Report Is depression associated with microvascular disease in patients with type 2 diabetes?† Thanh Tan Nguyen M.D., Thanh Tan Nguyen M.D. twong@unimelb.edu.au Centre for Eye Research Australia, University of Melbourne, Melbourne, VictoriaSearch for more papers by this authorTien Y. Wong M.D., Ph.D., Corresponding Author Tien Y. Wong M.D., Ph.D. Centre for Eye Research Australia, University of Melbourne, Melbourne, VictoriaCentre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, AustraliaSearch for more papers by this authorF.M. Amirul Islam Ph.D., F.M. Amirul Islam Ph.D. Centre for Eye Research Australia, University of Melbourne, Melbourne, VictoriaSearch for more papers by this authorLarry Hubbard M.A.T., Larry Hubbard M.A.T. Department of Ophthalmology and Visual Science, University of Wisconsin, Madison, WisconsinSearch for more papers by this authorJacqueline Miller M.D., Jacqueline Miller M.D. Department of Psychiatry, University of California Los Angeles, Los Angeles, CaliforniaSearch for more papers by this authorEbrahim Haroon M.D., Ebrahim Haroon M.D. Department of Psychiatry, University of California Los Angeles, Los Angeles, CaliforniaSearch for more papers by this authorChristine Darwin M.D., Christine Darwin M.D. Department of Internal Medicine, University of California Los Angeles, Los Angeles, CaliforniaSearch for more papers by this authorBarbara Esser B.Sc., M.S., Barbara Esser B.Sc., M.S. Department of Ophthalmology and Visual Science, University of Wisconsin, Madison, WisconsinSearch for more papers by this authorAnand Kumar M.D., Anand Kumar M.D. Department of Psychiatry, University of California Los Angeles, Los Angeles, CaliforniaSearch for more papers by this author Thanh Tan Nguyen M.D., Thanh Tan Nguyen M.D. twong@unimelb.edu.au Centre for Eye Research Australia, University of Melbourne, Melbourne, VictoriaSearch for more papers by this authorTien Y. Wong M.D., Ph.D., Corresponding Author Tien Y. Wong M.D., Ph.D. Centre for Eye Research Australia, University of Melbourne, Melbourne, VictoriaCentre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, AustraliaSearch for more papers by this authorF.M. Amirul Islam Ph.D., F.M. Amirul Islam Ph.D. Centre for Eye Research Australia, University of Melbourne, Melbourne, VictoriaSearch for more papers by this authorLarry Hubbard M.A.T., Larry Hubbard M.A.T. Department of Ophthalmology and Visual Science, University of Wisconsin, Madison, WisconsinSearch for more papers by this authorJacqueline Miller M.D., Jacqueline Miller M.D. Department of Psychiatry, University of California Los Angeles, Los Angeles, CaliforniaSearch for more papers by this authorEbrahim Haroon M.D., Ebrahim Haroon M.D. Department of Psychiatry, University of California Los Angeles, Los Angeles, CaliforniaSearch for more papers by this authorChristine Darwin M.D., Christine Darwin M.D. Department of Internal Medicine, University of California Los Angeles, Los Angeles, CaliforniaSearch for more papers by this authorBarbara Esser B.Sc., M.S., Barbara Esser B.Sc., M.S. Department of Ophthalmology and Visual Science, University of Wisconsin, Madison, WisconsinSearch for more papers by this authorAnand Kumar M.D., Anand Kumar M.D. Department of Psychiatry, University of California Los Angeles, Los Angeles, CaliforniaSearch for more papers by this author First published: 26 October 2007 https://doi.org/10.1002/da.20427Citations: 10 † This article is a US Government work and, as such, is in the public domain in the United States of America. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract We hypothesize that late-life depression is a manifestation of microvascular disease in patients with type 2 diabetes. We conducted a clinic-based cross-sectional study, comparing retinal vascular caliber, a marker of microvascular disease, in participants with type 2 diabetes with major depression (n=34), without depression (n=27) and healthy non-diabetic controls (n=38). Retinal vascular caliber was measured from digital retinal photographs using a validated computer-assisted method. After adjusting for age and gender, there was a trend of increasing retinal arteriolar caliber from healthy controls (132.6 μm), to diabetic patients without depression (139.2 μm), and diabetic patients with major depression (145.3 μm, P=0.008). The trend in retinal arteriolar caliber remains significant after adjusting for duration of diabetes, but not after further adjusting for vascular risk factors. Our findings suggest that there is variation in the retinal vascular caliber between type 2 diabetic patients with and without major depression and non-diabetic controls. This variation was largely related to poorer diabetes control and a higher frequency of vascular risk factors in diabetic patients, particularly those with depression. Studies with larger sample size may provide further insights into this association. Depression and Anxiety, 2008. Published 2007 Wiley-Liss, Inc. Citing Literature Volume25, Issue11November 2008Pages E158-E162 RelatedInformation