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Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City

2015; American Society for Microbiology; Volume: 59; Issue: 8 Linguagem: Inglês

10.1128/aac.00830-15

1098-6596

Amabel Lapuebla, Marie Abdallah, Olawole Olafisoye, Christopher Cortes, Carl Urban, David Landman, John Quale,

Pharmaceutical and Antibiotic Environmental Impacts

Imipenem with relebactam was active against Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp., including K. pneumoniae carbapenemase (KPC)-producing isolates. Loss of OmpK36 in KPC-producing K. pneumoniae isolates affected the susceptibility of this combination. Enhanced activity was evident against Pseudomonas aeruginosa, including isolates with depressed oprD and increased ampC expression. However, the addition of relebactam to imipenem did not provide added benefit against Acinetobacter baumannii. The combination of imipenem with relebactam demonstrated activity against KPC-producing Enterobacteriaceae and multidrug-resistant P. aeruginosa.