The Utility of the Transtubular Potassium Gradient in the Evaluation of Hyperkalemia
2008; American Society of Nephrology; Volume: 19; Issue: 3 Linguagem: Inglês
10.1681/asn.2007091017
ISSN1533-3450
AutoresMichael Choi, Fuad N. Ziyadeh,
Tópico(s)Potassium and Related Disorders
ResumoThe transtubular potassium gradient (TTKG) is used to gauge renal potassium secretion by the cortical collecting duct, indirectly assessing mineralocorticoid bioactivity in patients who have hypo- or hyperkalemia. TTKG values 2 during hypokalemia point to renal loss. Hypokalemia is not addressed here. Studies supporting the usefulness of the TTKG in hyperkalemia are limited to case series. This calculation may be most useful in distinguishing hyperkalemic patients who have mineralocorticoid deficiency versus resistance by observing a change in TTKG values after physiologic or pharmacologic doses of mineralocorticoids.
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