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EFFECTS OF PREMEDICATION ON DIPRIVAN INDUCTION

1982; Elsevier BV; Volume: 54; Issue: 9 Linguagem: Inglês

10.1093/bja/54.9.913

1471-6771

R.J. FREGEN, P.M. DE GROOD, E. N. Robertson, L.H.D.J. Booij, J. F. Crul,

Pharmacological Effects and Toxicity Studies

The effects of three premeditation regimens were compared in 45 healthy patients in whom anaesthesia was induced with diprivan 2mgkg-1 i.v Premedication with diazepam 10 mg orally and droperidol 2.5–5 Omg and piritramide 7.5–15.0 mg i.m. resulted in less pain on injection and a more profound sleep fro M. Dipnvan than premedication with diazepam 10 mg orally or no premedication. No differences in speed of induction were found when cessation of counting was used as a sign of unconsciousness. When the loss of eyelash reflex was used to define unconsciousness, the oral and i.m. premedication provided quicker induction after diprivan (39.3±2 9s) than no premedication (53.7±3.0s) (P