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Efficacy of Micafungin in Combination with Other Drugs in a Murine Model of Disseminated Trichosporonosis

2005; American Society for Microbiology; Volume: 49; Issue: 2 Linguagem: Inglês

10.1128/aac.49.2.497-502.2005

1098-6596

Carolina Serena, F. Javier Pastor, Félix Gilgado, Emilio Mayayo, Josep Guarro,

Plant Pathogens and Fungal Diseases

Using a murine model of disseminated infection caused by Trichosporon asahii, we have evaluated the efficacies of amphotericin B (AMB; 1 mg/kg of body weight/day), fluconazole (FLC; 20 mg/kg/twice a day), and micafungin (MFG; 5 mg/kg/twice a day). We tested these drugs alone and in combination (MFG with AMB and MFG with FLC). MFG with AMB showed a synergistic effect and demonstrated a higher degree of efficacy in prolonging survival and reducing the kidney fungal burden than either agent alone. The combination MFG with FLC was able to reduce significantly the kidney fungal burden in comparison to that achieved with either drug administered alone.