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ASSOCIATION BETWEEN OUTCOME AND TELOMERE DNA CONTENT IN PROSTATE CANCER

1999; Lippincott Williams & Wilkins; Volume: 162; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(05)68239-0

1527-3792

L A Donaldson, Colleen Fordyce, Frank D. Gilliland, Anthony Y. Smith, Richard M. Feddersen, Nancy E. Joste, Robert K. Moyzis, Jeffrey K. Griffith,

Immunotherapy and Immune Responses

No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Nov 1999ASSOCIATION BETWEEN OUTCOME AND TELOMERE DNA CONTENT IN PROSTATE CANCER LESLIE DONALDSON, COLLEEN FORDYCE, FRANK GILLILAND, ANTHONY SMITH, RICHARD FEDDERSEN, NANCY JOSTE, ROBERT MOYZIS, and JEFFREY GRIFFITH LESLIE DONALDSONLESLIE DONALDSON More articles by this author , COLLEEN FORDYCECOLLEEN FORDYCE More articles by this author , FRANK GILLILANDFRANK GILLILAND More articles by this author , ANTHONY SMITHANTHONY SMITH More articles by this author , RICHARD FEDDERSENRICHARD FEDDERSEN More articles by this author , NANCY JOSTENANCY JOSTE More articles by this author , ROBERT MOYZISROBERT MOYZIS More articles by this author , and JEFFREY GRIFFITHJEFFREY GRIFFITH More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)68239-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: To perform an initial retrospective investigation of the relationship between outcome in patients with organ confined prostate adenocarcinoma and the tumor cells’ content of telomere DNA. Materials and Methods: The case-controlled study group was composed of eighteen men diagnosed with prostatic adenocarcinoma prior to 1993. The group was selected so that approximately one half died within ten years of diagnosis and one half survived ten years or longer. Archival, paraffin-embedded tumor tissue was recovered for each patient. DNA was extracted from newly cut sections, fixed to nylon membranes and hybridized with P32-labeled centromere- and telomere-specific probes. Telomere DNA contents were quantitated from the hybridized radioactivities. The relationships between telomere DNA content and survival, and telomere DNA content and disease recurrence in men receiving prostatectomies were determined. Results: Death and disease recurrence were associated with reduced telomere DNA content (p <0.0001, p <0.0001, respectively). Conclusions: Telomere DNA content may differentiate high-risk patients with metastatic prostate cancer from men with indolent disease who can be spared the unnecessary side effects and expense of treatment by management with “watchful waiting.” References 1 Cancer Facts, National Cancer Institute, National Institutes of Health. Google Scholar 2 U.S. Preventative Services Task Force. Guide to Clinical Preventive Services, 10: Screening for Prostate Cancer. Google Scholar 3 : Genetic alterations in untreated metastases and androgen independent prostate cancer revealed by comparative genome hybridization. Cancer Res.1996; 56: 3091. Google Scholar 4 : Telomere crisis, the driving force in cancer cell evolution. Biochem. Biophys. Res. Com.1997; 230: 1. Google Scholar 5 : A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. USA1988; 85: 6622. Google Scholar 6 : Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. USA1992; 89: 10114. Google Scholar 7 : Telomere shortening is associated with cell division in vitro and in vivo. Exp. Cell Res.1995; 220: 194. Google Scholar 8 : Telomeres shorten during aging of human fibroblasts. Nature1990; 345: 458. Google Scholar 9 : Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J.1992; 11: 1921. Google Scholar 10 : Telomere reduction in human colorectal carcinoma and with aging. Nature1990; 346: 866. Google Scholar 11 : Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age. Proc. Natl. Acad. Sci. USA1994; 91: 9857. Google Scholar 12 : Structure and variability of human chromosome ends. Mol. Cell Biol.1990; 10: 518. Google Scholar 13 : Telomere length variation in normal and malignant human tissues. Genes Chrom. Cancer1994; 11: 171. Google Scholar 14 : Do telomerase antagonists represent a novel anti-cancer strategy?. Brit. J. Cancer1996; 73: 1. Google Scholar 15 : The stability of broken ends of chromosomes in Zea mays. Genetics1941; 26: 234. Google Scholar 16 : The fusion of broken ends of chromosomes following nuclear fusion. Proc. Natl. Acad. Sci. USA1942; 28: 458. Google Scholar 17 : Telomere reduction of specific chromosome translocation in acute myelocytic leukemia. Jpn. J. Cancer Res.1994; 85: 127. Google Scholar 18 : Alterations in telomeric repeat length in lung cancer are associated with loss of heterozygosity in p53 and Rb. Oncogene1995; 10: 937. Google Scholar 19 Griffith, J. K., Bryant, J. E., Fordyce, C. A., Gilliland, F. D., Joste, N. E. and Moyzis, R. K.: Reduced telomere DNA content is correlated with genomic instability and metastasis in human breast carcinoma. Breast Cancer Res. Treat. In press. Google Scholar 20 : Length of telomere repeats in neuroblastoma: correlation with prognosis and biological characteristics. Jpn. J. Cancer Res.1992; 83: 159. Google Scholar 21 : Telomere shortening associated with disease evolution patterns in myelodysplastic syndromes. Cancer Res.1994; 54: 3557. Google Scholar 22 : Telomere reduction in endometrial carcinoma. Am. J. Obstet. Gyn.1992; 167: 1883. Google Scholar 23 : Telomeres and telomerase: Biological and clinical importance. Clin. Chem.1997; 43: 708. Google Scholar 24 : Telomerase activity: A prevalent marker of malignant human prostate tissue. Cancer Res.1996; 56: 218. Google Scholar 25 : Telomerase activity in prostate cancer, prostatic intraepithelial neoplasia and benign prostatic epithelium. Cancer Res.1998; 58: 619. Google Scholar 26 : Telomerase activity in primary prostate cancer. J. Urol.1997; 157: 1161. Link, Google Scholar 27 : A sensitive measure of telomere DNA content in human tissues. BioTechniques1997; 23: 476. Google Scholar 28 : Specific association of human telomerase activity with immortal cells and cancer. Science1994; 266: 2011. Crossref, Medline, Google Scholar 29 : Detection of Telomerase activity in prostate needle-biopsy samples. Prostate1998; 36: 121. Google Scholar 30 : Telomerase activity, telomere length, and DNA ploidy in prostatic intraepithelial neoplasia (PIN). J. Urol.1998; 160: 1533. Link, Google Scholar 31 : Clinical significance of repeat sextant biopsies in prostate cancer patients. Urology1997; 49: 113. Google Scholar From the Department of Biochemistry and Molecular Biology, the Department of Medicine, the Department of Surgery, and the Department of Pathology, University of New Mexico School of Medicine, Albuquerque, and the Center for Human Genome Studies, Los Alamos National Laboratory, Los Alamos, New Mexico© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byGriebling T (2015) Re: Telomere Length as a Risk Factor for Hereditary Prostate CancerJournal of Urology, VOL. 193, NO. 5, (1542-1544), Online publication date: 1-May-2015.FORDYCE C, HEAPHY C, JOSTE N, SMITH A, HUNT W and GRIFFITH J (2018) ASSOCIATION BETWEEN CANCER-FREE SURVIVAL AND TELOMERE DNA CONTENT IN PROSTATE TUMORSJournal of Urology, VOL. 173, NO. 2, (610-614), Online publication date: 1-Feb-2005. Volume 162Issue 5November 1999Page: 1788-1792 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.Keywordsrecurrenceprostate cancermetastasistelomereprognosisoutcomeMetricsAuthor Information LESLIE DONALDSON More articles by this author COLLEEN FORDYCE More articles by this author FRANK GILLILAND More articles by this author ANTHONY SMITH More articles by this author RICHARD FEDDERSEN More articles by this author NANCY JOSTE More articles by this author ROBERT MOYZIS More articles by this author JEFFREY GRIFFITH More articles by this author Expand All Advertisement PDF downloadLoading ...