Transcriptional regulation of the cyclin D1 gene at a glance
2008; The Company of Biologists; Volume: 121; Issue: 23 Linguagem: Inglês
10.1242/jcs.039131
ISSN1477-9137
AutoresEric A. Klein, Richard K. Assoian,
Tópico(s)Wnt/β-catenin signaling in development and cancer
ResumoRegulated progression through the cell cycle requires sequential expression of a family of proteins called cyclins. Upon their induction, cyclins form complexes with specific cyclin-dependent kinases (CDKs), creating active holoenzymes that phosphorylate target proteins that are required for cell-
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