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Schwann Cell Internuclear Distances in Normal and Regenerating Unmyelinated Nerve Fibers

1973; American Medical Association; Volume: 29; Issue: 1 Linguagem: Inglês

10.1001/archneur.1973.00490250074009

1538-3687

J.M. Peyronnard, Albert J. Aguayo, Garth M. Bray,

Tissue Engineering and Regenerative Medicine

Schwann cell internuclear distances (INDs) were determined for unmyelinated nerve fiber bundles (Remak fibers) from rat cervical sympathetic trunks (CSTs) and sural nerves, which had been stained with cresyl violet and teased in a glycerin-water mixture. Internuclear distances varied along individual unmyelinated fiber bundles and from one bundle to another, ranging between 20μ to 250μ for CSTs and 20μ to 310μ for the sural nerve. Histograms for seven normal CSTs and the sural nerve were unimodal; median INDs for the CSTs were 90μ to 100μ, and for a normal sural nerve, 108μ. Schwann cell INDs were significantly reduced to 50μ to 60μ in CSTs regenerating after crush injury or transection. This suggests that in regenerating unmyelinated nerve fiber bundles, as in regenerating myelinated fibers, Schwann cell territories are shorter than normal.