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Adaptation to high altitude hypoxia as a factor preventing development of myocardial ischemic necrosis

1973; Elsevier BV; Volume: 31; Issue: 1 Linguagem: Inglês

10.1016/0002-9149(73)90806-0

1879-1913

Felix Z. Meerson, Oleg A. Gomzakov, M. V. Shimkovich,

Neuroscience of respiration and sleep

Adaptation to high altitude hypoxia reduces the mortality rate in rats with a ligated coronary artery by 5 or 6 times and the size of ischemic necrosis by 35 percent. This adaptation also minimizes the disturbances of the heart's contractile function in ischemic myocardial necrosis. The deficit in the contractile force during maximal load on the heart is 4.4 times smaller in rats adapted to hypoxia than in rats not so adapted. The primary factor contributing to the preventive effect of adaptation to high altitude hypoxia in ischemic necrosis is an increased capacity of the oxygen transport and utilization (mitochondrial) systems in the heart muscle of the adapted animals.