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Magnesium metabolism in hyperthyroidism and hypothyroidism.

1966; American Society for Clinical Investigation; Volume: 45; Issue: 6 Linguagem: Inglês

10.1172/jci105404

1558-8238

John E. Jones, Paul C. Desper, Stanley R. Shane, Edmund B. Flink,

Parathyroid Disorders and Treatments

In 1939, Hueber (1) reported clinical improve- ment in patients with thyrotoxicosis after paren- teral administration of magnesium.Wiswell (2) subsequently was unable to demonstrate any change in the peripheral metabolism of thyroid hormone in hyperthyroid patients given mag- nesium sulfate injections, whereas Neguib (3) reported a decrease in size of both toxic and nontoxic goiters and clinical improvement in three thyrotoxic patients given daily injections of magnesium chloride.Tapley (4) demonstrated that the administration of L-triiodothyronine promptly produced negative magnesium balance in two myxedematous patients and called attention to the similarity between the symptoms of thyrotoxico- sis and magnesium deficiency, as well as between myxedema and magnesium excess.That the se- rum magnesium is elevated in hypothyroidism and decreased in hyperthyroidism has long been known (5-7) but has recently been re-emphasized and as- sociated erythrocyte magnesium alterations re- ported (8).Dempsey and Astwood (9) demonstrated in- creased production of thyroid hormone in ani- mals maintained in the cold.Hegsted, Vitale, and McGrath (10) reported that the magnesium re- quirement to maintain maximal growth rates in animals kept at cold temperatures were four times *