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Inhibiting Protein-Protein Interactions as an Emerging Paradigm for Drug Discovery

2007; Bentham Science Publishers; Volume: 7; Issue: 2 Linguagem: Inglês

10.2174/138955707779802561

1875-5607

Juliet A. Gerrard, Craig A. Hutton, Matthew A. Perugini,

Synthesis and Reactivity of Heterocycles

Association of proteins into homo- and hetero-oligomers plays an important role in a plethora of biological phenomena. Inhibition of these interactions is increasingly recognized as a valuable new direction in drug design. In this mini-review we consider inhibition of protein misfolding and aggregation, molecules that disrupt enzyme quaternary structure, and signaling inhibitors, as emerging drugs. Keywords: Protein-protein interactions, inhibitor, amyloid, HIV, drug design, small molecule-protein interaction