Antagonlstic Effects on the Sinus Node of Acetylstrophanthidin and Adrenergic Stimulation
1963; Lippincott Williams & Wilkins; Volume: 13; Issue: 5 Linguagem: Inglês
10.1161/01.res.13.5.388
ISSN1524-4571
AutoresRéginald Nadeau, Thomas N. James,
Tópico(s)Cardiac pacing and defibrillation studies
ResumoHomeCirculation ResearchVol. 13, No. 5Antagonlstic Effects on the Sinus Node of Acetylstrophanthidin and Adrenergic Stimulation Free AccessResearch ArticlePDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessResearch ArticlePDF/EPUBAntagonlstic Effects on the Sinus Node of Acetylstrophanthidin and Adrenergic Stimulation Reginald A. Nadeau, M.D. and Thomas N. James, M.D. Reginald A. NadeauReginald A. Nadeau Section on Cardiovascular Research, Henry Ford Hospital, Detroit 2, Michigan and Thomas N. JamesThomas N. James Section on Cardiovascular Research, Henry Ford Hospital, Detroit 2, Michigan Originally published1 Nov 1963https://doi.org/10.1161/01.RES.13.5.388Circulation Research. 1963;13:388–391AbstractAcetylstrophanthidin perfused directly into the sinus node artery of the dog decreases the response of the sinus node to adrenergic stimulation. When sinus arrest followed per-fusion of high concentrations of glycosides, either sympathetic stimulation or intranodal epinephrine transiently restored sinus rhythm. Previous Back to top Next FiguresReferencesRelatedDetailsCited By Litonjua M, Penton S, Robinson C and Daubert G (2016) Digoxin: The Monarch of Cardiac Toxicities, Journal of Pharmacy Practice, 10.1177/0897190005276751, 18:3, (157-168), Online publication date: 1-Jun-2005. Rawles J (1992) The Management of Atrial Fibrillation Atrial Fibrillation, 10.1007/978-1-4471-1898-5_10, (199-233), . Steinbeck G (1986) Diagnostische Elektrostimulation Herzschrittmacher, 10.1007/978-3-642-70471-0_3, (51-90), . Rosen M (1985) Cellular electrophysiology of digitalis toxicity, Journal of the American College of Cardiology, 10.1016/S0735-1097(85)80460-5, 5:5, (22A-34A), Online publication date: 1-May-1985. Achenbach C, Engel J, Heusinger J and Metzenauer P (1985) Acrihellin, Cardiovascular Drug Reviews, 10.1111/j.1527-3466.1985.tb00480.x, 3:1, (219-243), Online publication date: 1-Mar-1985. Alboni P, Shantha N, Filippi L, Pirani R, Preziosi S, Tomasi A and Masoni A (1984) Clinical effects of digoxin on sinus node and atrioventricular node function after pharmacologic autonomic blockade, American Heart Journal, 10.1016/0002-8703(84)90750-6, 108:5, (1255-1261), Online publication date: 1-Nov-1984. Smith T, Antman E, Friedman P, Blatt C and Marsh J (1984) Part III Digitalis glycosides: Mechanisms and manifestations of toxicity, Progress in Cardiovascular Diseases, 10.1016/0033-0620(84)90018-5, 27:1, (21-56), Online publication date: 1-Jul-1984. Cook L, Doherty J, Elkins R and Straub K (1984) Comparison of the canine tissue distribution of digoxin after acute and chronic administration: Implications for digitalis therapy, The American Journal of Cardiology, 10.1016/0002-9149(84)90606-4, 53:11, (1703-1706), Online publication date: 1-Jun-1984. Smith T, Antman E, Friedman P, Blatt C and Marsh J (1984) Part II Digitalis glycosides: Mechanisms and manifestations of toxicity, Progress in Cardiovascular Diseases, 10.1016/0033-0620(84)90014-8, 26:6, (495-540), Online publication date: 1-May-1984. Smith T, Antman E, Friedman P, Blatt C and Marsh J (1984) Part I Digitalis glycosides: Mechanisms and manifestations of toxicity, Progress in Cardiovascular Diseases, 10.1016/0033-0620(84)90012-4, 26:5, (413-458), Online publication date: 1-Mar-1984. James T (1983) Primary and secondary cardioneuropathies and their functional significance, Journal of the American College of Cardiology, 10.1016/S0735-1097(83)80250-2, 2:5, (983-1002), Online publication date: 1-Nov-1983. Treese N, Kasper W, Gilfrich H, Pop T and Mcinertz T (1983) Influence of digoxin on sinus node function after pharmacologic autonomic blockadeDer Einflu� von Digoxin auf die Sinusknotenfunktion nach pharmakologischer autonomer Blockade, Klinische Wochenschrift, 10.1007/BF01488720, 61:10, (523-527), Online publication date: 1-May-1983. Steinbeck G (1983) Kontraindikationen Therapie mit Herzglykosiden, 10.1007/978-3-642-69046-4_9, (99-107), . Nawrath H (1983) Wirkungsspektrum der Herzglykoside Herzrhythmusstörungen, 10.1007/978-3-642-68872-0_7, (237-250), . Hoffman B (1983) The pharmacology of cardiac glycosides Cardiac therapy, 10.1007/978-1-4613-3855-0_11, (387-412), . Hariman R and Hoffman B (1982) Effects of ouabain and vagal stimulation on sinus nodal function in conscious dogs., Circulation Research, 51:6, (760-768), Online publication date: 1-Dec-1982. Kreutzberger A and Leger M (1981) Antiarrhythmika. I. 2,4-dialkylpyrimido[1,2- a ]benzimidazole , Journal of Heterocyclic Chemistry, 10.1002/jhet.5570180819, 18:8, (1587-1588), Online publication date: 1-Dec-1981. Gomes J, Kang P and El-Sherif N (1981) Effects of digitalis on the human sick sinus node after pharmacologic autonomic blockade, The American Journal of Cardiology, 10.1016/0002-9149(81)90158-2, 48:4, (783-788), Online publication date: 1-Oct-1981. Joubert P (1981) Effects of Cardiac Glycosides on Autonomic Nervous System and Endocrine Glands Cardiac Glycosides, 10.1007/978-3-642-68163-9_24, (533-550), . Lathers C and Roberts J (1980) Digitalis cardiotoxicity revisited, Life Sciences, 10.1016/0024-3205(80)90439-7, 27:19, (1713-1733), Online publication date: 1-Nov-1980. Lathers C (1980) Effect of timolol on autonomic neural discharge associated with ouabain-induced arrhythmia, European Journal of Pharmacology, 10.1016/0014-2999(80)90032-1, 64:2-3, (95-106), Online publication date: 1-Jun-1980. Steinbeck G, Bonke F, Allessie M and Lammers W (1980) The effect of ouabain on the isolated sinus node preparation of the rabbit studied with microelectrodes., Circulation Research, 46:3, (406-414), Online publication date: 1-Mar-1980. Reiffel J, Bigger J and Cramer M (1979) Effects of digoxin on sinus nodal function before and after vagal blockade in patients with sinus nodal dysfunction, The American Journal of Cardiology, 10.1016/0002-9149(79)90364-3, 43:5, (983-989), Online publication date: 1-May-1979. Arora R and Madan B (1979) Antiarrhythmic action of minor and major tranquilizers, Pharmacology & Therapeutics, 10.1016/0163-7258(79)90008-1, 4:3, (633-656), Online publication date: 1-Jan-1979. Lüderitz B (1979) Literatur Elektrische Stimulation des Herzens, 10.1007/978-3-642-67169-2_7, (352-382), . Gillis R, Helke C, Kellar K and Quest J (1978) Autonomic nervous system actions of cardiac glycosides, Biochemical Pharmacology, 10.1016/0006-2952(78)90408-2, 27:6, (849-856), Online publication date: 1-Mar-1978. Steinbeck G, Bonke F, Allessie M and Lammers W (1978) Cardiac Glycosides and Pacemaker Activity of the Sinus Node — A Microelectrode Study on the Isolated Right Atrium of the Rabbit The Sinus Node, 10.1007/978-94-009-9715-8_21, (258-269), . James T (1977) Small arteries of the heart., Circulation, 56:1, (2-14), Online publication date: 1-Jul-1977. Geer M, Wagner G, Waxman M and Wallace A (1977) Chronotropic effect of acetylstrophanthidin infusion into the canine sinus nodal artery, The American Journal of Cardiology, 10.1016/S0002-9149(77)80129-X, 39:5, (684-689), . Porlier G, Elharrar V, Gauthier P and Nadeau R (1976) The effects of acetylstrophanthidin on the response of the AV junction to adrenergic stimulation studied in dogs, American Heart Journal, 10.1016/S0002-8703(76)80330-4, 91:4, (475-483), Online publication date: 1-Apr-1976. Rosen M, Wit A and Hoffman B (1975) Electrophysiology and pharmacology of cardiac arrhythmias. IV. Cardiac antiarrhythmic and toxic effects of digitalis, American Heart Journal, 10.1016/0002-8703(75)90090-3, 89:3, (391-399), Online publication date: 1-Mar-1975. Pearle D and Gillis R (1974) Effect of digitalis on response of the ventricular pacemaker to sympathetic neural stimulation and to isoproterenol, The American Journal of Cardiology, 10.1016/0002-9149(74)90161-1, 34:6, (704-710), Online publication date: 1-Nov-1974. Angus J, Richmond D, Cobbin L and Goodman A (2008) A Comparison of the Cardiovascular Effects of Proscillaridin and Ouabain in Anaesthetised Dogs, Australian and New Zealand Journal of Medicine, 10.1111/j.1445-5994.1973.tb03114.x, 3:4, (404-409), Online publication date: 1-Aug-1973. Leachman R, Cokkinos D, Cabrera R, Leatherman L and Rochelle D (1971) Response of the transplanted, denervated human heart to cardiovascular drugs, The American Journal of Cardiology, 10.1016/0002-9149(71)90302-X, 27:3, (272-276), Online publication date: 1-Mar-1971. Roberts J (1970) The action of ouabain on the chronotropic effects of sympathetic nerve stimulation and isoproterenol, European Journal of Pharmacology, 10.1016/0014-2999(70)90022-1, 12:1, (1-9), Online publication date: 1-Sep-1970. Ten Eick R and Hoffman B (1969) Chronotropic Effect of Cardiac Glycosides in Cats, Dogs, and Rabbits, Circulation Research, 25:4, (365-378), Online publication date: 1-Oct-1969. Singer D and Ten Eick R (1969) Pharmacology of cardiac arrhythmias, Progress in Cardiovascular Diseases, 10.1016/0033-0620(69)90003-6, 11:6, (488-514), Online publication date: 1-May-1969. Georgopoulos A, Karapistolis H and Tountas C (1969) Effects of digitalization and beta-adrenergic blockade on arrhythmias induced by the direct current defibrillator, Pharmacologia Clinica, 10.1007/BF00404657, 1:3, (119-122), Online publication date: 1-Mar-1969. Roberge G, Hood W and Lown B (1968) Digitalization of the myocardium in the intact animal by direct coronary artery drug administration, The American Journal of Cardiology, 10.1016/0002-9149(68)90322-6, 21:2, (213-222), Online publication date: 1-Feb-1968. Szekeres L and Papp J (1968) Antiarrhythmic Compounds Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, 10.1007/978-3-0348-7065-8_5, (292-369), . EICK R, WYTE S, ROSS S and HOFFMAN B (1967) Post-Countershock Arrhythmias in Untreated and Digitalized Dogs, Circulation Research, 21:3, (375-390), Online publication date: 1-Sep-1967. Hoffman B and Singer D (1964) Effects of digitalis on electrical activity of cardiac fibers, Progress in Cardiovascular Diseases, 10.1016/S0033-0620(64)80021-9, 7:3, (226-260), Online publication date: 1-Nov-1964. James T and Nadeau R (1964) The mechanism of action of quinidine on the sinus node studied by direct perfusion through its artery, American Heart Journal, 10.1016/0002-8703(64)90181-4, 67:6, (804-811), Online publication date: 1-Jun-1964. November 1, 1963Vol 13, Issue 5 Advertisement Article InformationMetrics © 1963 American Heart Association, Inc.https://doi.org/10.1161/01.RES.13.5.388 Manuscript receivedMay 13, 1963Originally publishedNovember 1, 1963 PDF download Advertisement
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