Portal de Periódicos da CAPES

Dienogest and the breast

2009; Informa; Volume: 25; Issue: 7 Linguagem: Inglês

10.1080/09513590902836536

1473-0766

Adolf E. Schindler, Alexandria Henkel, Bernd Christensen, Michel Oettel, Claudia Moore,

Menopause: Health Impacts and Treatments

In a clinical pilot study, 21 women with endometriosis have been primarely treated with dienogest 2 x 10 mg daily p.o. for 24 weeks. Besides the effect on endometriosis the action of such high-dose progestogen treatment on the breast was evaluated by breast ultrasound prior to medication and at 24 weeks of medical treatment. In all women, a significant size reduction of the mammary gland (p < 0.023) and regression of mastopathic changes were observed. There was a non-significant reduction (p = 0.089) of the maximum diameter of the ducts. The portion of the fatty tissue increased slightly, but not significantly (p = 0.348).