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Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

2009; Nature Portfolio; Volume: 41; Issue: 10 Linguagem: Inglês

10.1038/ng.450

1546-1718

Rosalind A. Eeles, Zsofia Kote‐Jarai, Ali Amin Al Olama, Graham G. Giles, Michelle Guy, Gianluca Severi, Kenneth Muir, John L. Hopper, Brian E. Henderson, Christopher A. Haiman, Johanna Schleutker, Freddie C. Hamdy, David E. Neal, Jenny Donovan, Janet L. Stanford, Elaine A. Ostrander, Sue A. Ingles, Esther M. John, Stephen N. Thibodeau, Daniel J. Schaid, Jong Y. Park, Amanda B. Spurdle, Judith A. Clements, Joanne L. Dickinson, Christiane Maier, Walther Vogel, Thilo Dörk, Timothy R. Rebbeck, Kathleen A. Cooney, Lisa Cannon‐Albright, Pierre O. Chappuis, Pierre Hutter, Maurice P. Zeegers, Radka Kaneva, Hongwei Zhang, Yong‐Jie Lu, William D. Foulkes, Dallas R. English, Daniel Leongamornlert, Malgorzata Tymrakiewicz, Jonathan J. Morrison, Audrey Ardern‐Jones, Amanda L. Hall, Lynne T. O'Brien, Rosemary Wilkinson, Edward J. Saunders, Elizabeth Page, Emma J Sawyer, Stephen M. Edwards, David P. Dearnaley, Alan Horwich, Robert Huddart, Vincent Khoo, Christopher Parker, Nicholas van As, Christopher Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin S. Cooper, Melissa C. Southey, Artitaya Lophatananon, Jo‐Fen Liu, Laurence N. Kolonel, Loı̈c Le Marchand, Tiina Wahlfors, Teuvo L.J. Tammela, Anssi Auvinen, Sarah J. Lewis, Angela Cox, Liesel M. FitzGerald, Joseph S. Koopmeiners, Danielle M. Karyadi, Erika M. Kwon, Mariana C. Stern, Román Corral, Amit D. Joshi, Ahva Shahabi, Shannon K. McDonnell, Thomas A. Sellers, Julio M. Pow‐Sang, Suzanne K. Chambers, Joanne F. Aitken, Robert A. Gardiner, Jyotsna Batra, Mary Anne Kedda, Felicity Lose, Andrea Polanowski, Briony Patterson, Jürgen Serth, Andreas Meyer, Manuel Luedeke, Klara Stefflova, Anna M. Ray, Ethan M. Lange, James M. Farnham, Humera Khan, Chavdar Slavov, A. Mitkova, Guangwen Cao, Douglas F. Easton,

Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Rosalind Eeles and colleagues present a genome-wide association study for prostate cancer. They report seven loci newly associated with prostate cancer susceptibility. Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 × 10−8 to P = 2.7 × 10−33).