Imidomethylation of C-nucleophiles using O-phthalimidomethyl trichloroacetimidate and catalytic amounts of TMSOTf
2004; Elsevier BV; Volume: 60; Issue: 22 Linguagem: Inglês
10.1016/j.tet.2004.04.011
ISSN1464-5416
AutoresImran Ali, El Sayed H. El Ashry, Richard R. Schmidt,
Tópico(s)Chemical Synthesis and Reactions
ResumoThe O-phthalimidomethyl trichloroacetimidate (1), as a latent aminomethylating agent, exhibits high electrophilicity towards a variety of C-nucleophiles in the presence of catalytic amounts of TMSOTf and mild reaction conditions. The nucleophiles include aromatics, alkenes and active methylene compounds 2–11 whereby a phthalimidomethyl group could be introduced to give compounds 12–22. Removal of the phthaloyl group gave the respective amines, β-amino ketones, and β-amino acids. The O-(trichloroacetamido)methyl trichloroacetimidate (35) was also found to be a good amidomethylating agent.
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