Artigo Acesso aberto Revisado por pares

Vascular endothelial growth factor-B expression in postischemic rat brain

2013; BioMed Central; Volume: 5; Issue: 1 Linguagem: Inglês

10.1186/2045-824x-5-8

ISSN

2045-824X

Autores

Lin Xie, XiaoOu Mao, Kunlin Jin, David A. Greenberg,

Tópico(s)

Axon Guidance and Neuronal Signaling

Resumo

Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain.We examined VEGF-B expression by immunohistochemistry in the ischemic border zone 1-7 days after middle cerebral artery occlusion in rats.VEGF-B immunoreactivity in the border zone was increased after middle cerebral artery occlusion and was associated with neurons and macrophages/microglia, but not astrocytes or endothelial cells.These findings provide additional evidence for a role of VEGF-B in the endogenous response to cerebral ischemia.

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