Micropenis: Does Early Treatment with Testosterone Do More Harm Than Good?
1995; Lippincott Williams & Wilkins; Volume: 154; Issue: 2 Linguagem: Inglês
10.1016/s0022-5347(01)67175-1
ISSN1527-3792
AutoresDaniel R. McMahon, S.A. Kramer, Douglas A. Husmann,
Tópico(s)Ovarian function and disorders
ResumoNo AccessJournal of UrologyExternal Genitalia1 Aug 1995Micropenis: Does Early Treatment with Testosterone Do More Harm Than Good? D.R. McMahon, S.A. Kramer, and D. A.* Husmann D.R. McMahonD.R. McMahon More articles by this author , S.A. KramerS.A. Kramer More articles by this author , and D. A.* HusmannD. A.* Husmann More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)67175-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Micropenis secondary to hypogonadotropic hypogonadism was induced in the Sprague-Dawley rat using long acting microspheres of the gonadotropic agonist leuprolide acetate. Following the induction of micropenis treatment was initiated with testosterone at day 7, 28, 56 or 84 of life. All treatment protocols resulted in improved phallic growth compared to the untreated animals with micropenis (p less than 0.01). Treatment of animals with testosterone beginning on day 7 of life resulted in premature growth of the penis and the redevelopment of micropenis in adulthood. In contrast, delaying testosterone therapy until day 56 (pubertal) or 84 (early postpubertal) resulted in complete penile development. These findings suggest that early exposure of the penis to androgens in childhood may eventually result in a significant reduction of phallic size in adulthood. References 1 : Micropenis: adult follow-up and comparison of size against new norms. J. Sex Martial Ther.1984; 10: 105. Google Scholar 2 : Small penis and the male sexual role. J. Urol.1989; 142: 569. Link, Google Scholar 3 : Microphallus: clinical and endocrinological characteristics. J. Urol.1978; 119: 750. Link, Google Scholar 4 : The many difficulties of managing micropenis. Contemp. Urol.June 1993; : 15. Google Scholar 5 : Microphallus: eventual phallic size is dependent on the timing of androgen administration. J. 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Google Scholar Mayo Clinic, Rochester, Minnesota.© 1995 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byCanning D (2018) PEDIATRIC UROLOGYJournal of Urology, VOL. 163, NO. 1, (378-382), Online publication date: 1-Jan-2000.Husmann D (2018) EDITORIAL: MICROPHALLIC HYPOSPADIAS-THE USE OF HUMAN CHORIONIC GONADOTROPIN AND TESTOSTERONE BEFORE SURGICAL REPAIRJournal of Urology, VOL. 162, NO. 4, (1440-1441), Online publication date: 1-Oct-1999.TIETJEN D, URAMOTO G, TINDALL D and HUSMANN D (2018) MICROPENIS IN HYPOGONADOTROPIC HYPOGONADISM: RESPONSE OF THE PENILE ANDROGEN RECEPTOR TO TESTOSTERONE TREATMENTJournal of Urology, VOL. 160, NO. 3 Part 2, (1054-1057), Online publication date: 1-Sep-1998.Levy J, Seay T, Tindall D and Husmann D (2018) The Effects of Androgen Administration on Phallic Androgen Receptor ExpressionJournal of Urology, VOL. 156, NO. 2S, (775-779), Online publication date: 1-Aug-1996.Levy J and Husmann D (2018) Congenital Adrenal Hyperplasia: Is there an Effect on Penile Growth?Journal of Urology, VOL. 156, NO. 2S, (780-782), Online publication date: 1-Aug-1996.Sutherland R, Kogan B, Baskin L, Mevorach R, Conte F, Kaplan S and Grumbach M (2018) The Effect of Prepubertal Androgen Exposure on Adult Penile LengthJournal of Urology, VOL. 156, NO. 2S, (783-787), Online publication date: 1-Aug-1996. Volume 154Issue 2August 1995Page: 825-829 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.MetricsAuthor Information D.R. McMahon More articles by this author S.A. Kramer More articles by this author D. A.* Husmann More articles by this author Expand All Advertisement PDF downloadLoading ...
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