Envelope-Constrained Neutralization-Sensitive HIV-1 After Heterosexual Transmission
2004; American Association for the Advancement of Science; Volume: 303; Issue: 5666 Linguagem: Inglês
10.1126/science.1093137
ISSN1095-9203
AutoresCynthia A. Derdeyn, Julie M. Decker, Frédéric Bibollet‐Ruche, John L. Mokili, Mark Muldoon, Scott A. Denham, Marintha Heil, Francis Kasolo, Rosemary Musonda, Beatrice H. Hahn, George M. Shaw, Bette Korber, Susan Allen, Eric Hunter,
Tópico(s)HIV/AIDS drug development and treatment
ResumoHeterosexual transmission accounts for the majority of human immunodeficiency virus–1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.
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