Commentary to ‘Astrocyte elevated gene-1 overexpression in histologically favorable Wilms tumor is related to poor prognosis’
2013; Elsevier BV; Volume: 10; Issue: 2 Linguagem: Inglês
10.1016/j.jpurol.2013.09.013
ISSN1873-4898
Autores Tópico(s)Urological Disorders and Treatments
ResumoA genomic approach to developing biomarkers for Wilms' tumor is used by both the Children's Oncology Group (COG) and the International Society of Paediatric Oncology (SIOP) [ 1 Dome J.S. Fernandez C.V. Mullen E.A. Kalapurakal J.A. Geller J.I. Huff V. et al. Children's oncology group's 2013 blueprint for research: renal tumors. Pediatr Blood Cancer. 2013; 80: 994-1000 Crossref Scopus (119) Google Scholar , 2 Perotti D. Spreafico F. Torri F. Gamba B. D’Adamo P. Pizzamiglio S. et al. Genomic profiling by whole-genome single nucleotide polymorphism arrays in Wilms' tumor and association with relapse. Gene Chromosome Canc. 2012; 51: 644-653 Crossref PubMed Scopus (25) Google Scholar , 3 Watson J.A. Bryan K. Williams R. Popov S. Vujanic G. Coulomb A. et al. miRNA profiles as a predictor of chemoresponsiveness in Wilms’ tumor blastema. PLOS One. 2013; 8: e53417 Crossref PubMed Scopus (56) Google Scholar , 4 Spreafico F. Gamba B. Mariani L. Collini P. D’Angelo P. Pession A. et al. Loss of heterozygosity analysis at different chromosome regions in Wilms' tumor confirms 1p allelic loss as a marker of worse prognosis: a study from the Italian Association of Pediatric Hematology and Oncology. J Urol. 2013; 189: 260-267 Abstract Full Text Full Text PDF PubMed Scopus (23) Google Scholar ]. A benefit to central pathological review for COG and SIOP trials is the ability to assess the utility of proposed biomarkers in a large patient set with known treatment regimens and outcomes. The combined loss of heterozygosity (LOH) at 1p and 16q is part of the risk stratification for favorable histology in the current COG protocol, and the use of retention of imprinting at 11p15 and gain at 1q are proposed for future protocols [ [1] Dome J.S. Fernandez C.V. Mullen E.A. Kalapurakal J.A. Geller J.I. Huff V. et al. Children's oncology group's 2013 blueprint for research: renal tumors. Pediatr Blood Cancer. 2013; 80: 994-1000 Crossref Scopus (119) Google Scholar ]. The purpose of these markers is to select out patients with favorable histology Wilms' tumors who would benefit from more intensive chemotherapy regimens owing to risk of recurrence. LOH at 1p and 16q [ [1] Dome J.S. Fernandez C.V. Mullen E.A. Kalapurakal J.A. Geller J.I. Huff V. et al. Children's oncology group's 2013 blueprint for research: renal tumors. Pediatr Blood Cancer. 2013; 80: 994-1000 Crossref Scopus (119) Google Scholar ], and B7-h1 [ [5] Routh J.C. Grundy P.E. Anderson J.R. Retik A.B. Kurek K.C. B7-h1 as a biomarker for therapy failure in patients with favorable histology Wilms tumor. J Urol. 2013; 189: 1487-1492 Abstract Full Text Full Text PDF PubMed Scopus (22) Google Scholar ] remain predictive after correcting for clinical stage, but one of the challenges is that LOH at 1p and 16q only occurs in 3–4% of patients [ [4] Spreafico F. Gamba B. Mariani L. Collini P. D’Angelo P. Pession A. et al. Loss of heterozygosity analysis at different chromosome regions in Wilms' tumor confirms 1p allelic loss as a marker of worse prognosis: a study from the Italian Association of Pediatric Hematology and Oncology. J Urol. 2013; 189: 260-267 Abstract Full Text Full Text PDF PubMed Scopus (23) Google Scholar ], limiting its clinical impact. This article introduces astrocyte elevated gene-1 (AEG-1) histology as a potential biomarker. I am concerned that AEG-1 histology tracks so closely with clinical stage. As clinical stage increases, the percentage of high expression increases significantly from 28% in stage I patients to 100% (1/1) in stage IV patients. Therefore, while AEG-1 may predict a worse outcome and is widely expressed, the question remains whether it provides additional information compared to clinical stage alone. Astrocyte elevated gene-1 overexpression in histologically favorable Wilms tumor is related to poor prognosisJournal of Pediatric UrologyVol. 10Issue 2PreviewAstrocyte elevated gene-1 (AEG-1) is associated with tumorigenesis and progression in various types of human cancers. However, the status of AEG-1 expression and its significance in Wilms tumor are still unclear. In this study, we investigated the expression of AEG-1 and evaluated its clinical and prognostic significance in favorable-histology Wilms tumor (FHWT). Full-Text PDF
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