Artigo Revisado por pares

Effects of Seprafilm on peritoneal fibrinolytic system

2005; Wiley; Volume: 75; Issue: 8 Linguagem: Inglês

10.1111/j.1445-2197.2005.03483.x

ISSN

1445-2197

Autores

Ömer Rıdvan Tarhan, Ahmet Eroğlu, Recep Çetin, Ayper Ynce, Mahmut Bülbül, Yrfan Altuntas,

Tópico(s)

Electrolyte and hormonal disorders

Resumo

Background: There is a high incidence of adhesions after ventral hernia repair with polypropylene mesh. The purpose of the present study was to evaluate the efficacy of Seprafilm in the prevention of adhesion formation and effect on peritoneal fibrinolytic activity. Methods: An incisional hernia model was created in rats. In the experimental group Seprafilm was placed between polypropylene mesh and abdominal organs. On the 14th day adhesions were evaluated and tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), plasminogen activator inhibitor (PAI) type 1 and 2 were measured in peritoneal biopsy specimens. Results: Adhesions were significantly reduced in the Seprafilm group ( P = 0.002). Nevertheless, there were no difference between the two groups in levels of tPA, PAI‐1 and PAI‐2. However, the levels of uPA were significantly decreased in the Seprafilm group. Conclusions: The adhesion preventive effect of Seprafilm is not directly related in peritoneal fibrinolytic activity. Instead, the physical properties (barrier, hydroflotation and sliconizing effect) of the membrane are primarily responsible for adhesion prevention.

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