Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii-infected mice
2000; Springer Science+Business Media; Volume: 5; Issue: 4 Linguagem: Inglês
10.1379/1466-1268(2000)005 2.0.co;2
ISSN1466-1268
AutoresHye-Seong Mun, Fumie Aosai, Kazumi Norose, Mei Chen, Hidekazu Hata, Yoh‐ichi Tagawa, Yoichiro Iwakura, Dae‐Seok Byun, Akihiko Yano,
Tópico(s)T-cell and Retrovirus Studies
ResumoToxoplasma gondii Hsp70, T gondii Hsp30/bag1, and surface antigen 1 messenger RNAs were shown to be useful in analyzing stage conversion of T gondii between bradyzoites and tachyzoites. The high-level expression of T gondii Hsp70 was correlated with mortality in interferon-gamma knockout mice infected with T gondii. Tgondii Hsp70 inhibited the induction of nitric oxide release by peritoneal macrophages of T gondii-infected mice. These findings identify T gondii Hsp70 as a danger signal during lethal, acute T gondii infection.
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