Produção Nacional
Revisado por pares
Antitumor, antibiotic and antileishmanial properties of the Pyranonaphthoquinone Psychorubrin from Mitracarpus frigidus
2012; Brazilian Academy of Sciences; Volume: 84; Issue: 4 Linguagem: Inglês
10.1590/s0001-37652012005000064
ISSN1678-2690
AutoresRodrigo Luiz Fabri, Richard Michael Grazul, Lidiane Oliveira de Carvalho, Elaine Soares Coimbra, Gabriele Mendes Matos Cardoso, Elaine M. Souza–Fagundes, Adilson David da Silva, Elita Scio,
Tópico(s)Morinda citrifolia extract uses
ResumoThe bioactivity guided fractionation of the dichloromethane extract of Mitracarpus frigidus afforded the pyranonaphthoquinone psychorubrin. This compound, hitherto unknown in the genus Mitracarpus, had its biological activity evaluated against one panel of bacteria and two fungi, three tumor cell lines (HL60, Jurkat and MCF-7) and four Leishmania species. Its identity was confirmed unambiguously by ¹H, 13C, ¹H-COSY, IR and UV-Vis spectroscopy and mass spectrometry. Psychorubrin displayed a very promising antitumor with IC50 of 4.5, 5.6 and 1.1 µM for HL60, Jurkat and MCF-7 cell lines, respectively. Antimicrobial activity, mainly against Cryptococcus neoformans (MIC of 87.3 µM) was observed. A pronounced antileishmanial potential was also verified with IC50 varying from 1.7 to 2.7 µM for the Leishmania species tested. This is the first report of the presence of pyranonapthoquinones in the Mitracarpus genus, which may serve as a chemotaxonomical marker.
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