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Molecular modeling of a T-cell receptor bound to a major histocompatibility complex molecule: Implications for T-cell recognition

1995; Wiley; Volume: 4; Issue: 9 Linguagem: Inglês

10.1002/pro.5560040906

1469-896X

Juan C. Almagro, Enrique Vargas‐Madrazo, Francisco Lara‐Ochoa, E. Horjales,

Immune Cell Function and Interaction

Protein ScienceVolume 4, Issue 9 p. 1708-1717 ArticleFree Access Molecular modeling of a T-cell receptor bound to a major histocompatibility complex molecule: Implications for T-cell recognition Juan C. Almagro, Corresponding Author Juan C. Almagro almagro@vincent.iquimica.unam.mx Institute de Quimica, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, CP. 04510, México, D.FInstituto de Quimica, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, CP. 04510, México, D.F.Search for more papers by this authorEnrique Vargas-Madrazo, Enrique Vargas-Madrazo Instituto de Investigaciones Biológicas, Universidad Veracruzana, Xalapa, Veracruz, MéxicoSearch for more papers by this authorFrancisco Lara-Ochoa, Francisco Lara-Ochoa Institute de Quimica, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, CP. 04510, México, D.FSearch for more papers by this authorEduardo Horjales, Eduardo Horjales Institute de Quimica, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, CP. 04510, México, D.FSearch for more papers by this author Juan C. Almagro, Corresponding Author Juan C. Almagro almagro@vincent.iquimica.unam.mx Institute de Quimica, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, CP. 04510, México, D.FInstituto de Quimica, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, CP. 04510, México, D.F.Search for more papers by this authorEnrique Vargas-Madrazo, Enrique Vargas-Madrazo Instituto de Investigaciones Biológicas, Universidad Veracruzana, Xalapa, Veracruz, MéxicoSearch for more papers by this authorFrancisco Lara-Ochoa, Francisco Lara-Ochoa Institute de Quimica, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, CP. 04510, México, D.FSearch for more papers by this authorEduardo Horjales, Eduardo Horjales Institute de Quimica, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, CP. 04510, México, D.FSearch for more papers by this author First published: September 1995 https://doi.org/10.1002/pro.5560040906Citations: 10AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract The main functions of the T-cell receptor (TCR) involve its specific interaction with short and linear antigenic peptides bound to the major histocompatibility complex (MHC) molecules. In the absence of a 3D structure for TCR and for the TCR/peptide/MHC complex, several attempts to characterize the structural components of the TCR/peptide/MHC interaction have been made. However, this subject is still troublesome. In this paper a computer-based 3D model for a TCR/peptide/MHC complex (5C.C7/moth cytochrome c [MCC] peptide 93–103/I-Ek) was obtained. The complex surface shows a high complementarity between the 5C.C7 structure and the peptide/I-Ek molecule. The mapping of residues involved in the TCR/peptide/MHC interaction shows close agreement with mutational experiments (Jorgensen JL, Reay PA, Ehrich EW, Davis MM, 1992b, Annu Rev Immunol 70:835–873). 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An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity. J Exp Med 132: 211– 250. Citing Literature Volume4, Issue9September 1995Pages 1708-1717 ReferencesRelatedInformation