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Síntese e atividade antibacteriana de imidas cíclicas: 3,4-dicloromaleimidas e 3-cloro-4-substituída-maleimidas

1998; Brazilian Chemical Society; Volume: 21; Issue: 5 Linguagem: Inglês

10.1590/s0100-40421998000500008

1678-7064

Adriano D. Andricopulo, Rosendo Augusto Yunes, Ricardo José Nunes, Alessandro O. S. Savi, Rogério Corrêa, Alexandre Bella Cruz, Valdir Cechinel Filho,

Synthesis and biological activity

3,4 DICHLOROMALEIM-IDES AND 3-CHLORO-4-SUBSTITUTED-MALEIMIDES.In the present study, new N-aryl and Nalkylarylcyclic imides were synthesized and their antibacterial properties against Escherichia coli and Staphylococcus aureus were evaluated by using the diffusion method.All compounds were obtained in good yield (54 -95%) and characterized by spectral data ( 1 H-NMR, MS, IR) and elemental analysis (CHN).The biological results indicated that some compounds exert significative antibacterial effects, confirming previous studies on biological activities of cyclic imides.