Portal de Periódicos da CAPES

THE MOLECULAR STRUCTURE OF CELL ADHESION MOLECULES

1997; Annual Reviews; Volume: 66; Issue: 1 Linguagem: Inglês

10.1146/annurev.biochem.66.1.823

1545-4509

Cyrus Chothia, E. Yvonne Jones,

Axon Guidance and Neuronal Signaling

Considerable advances have been made in our knowledge of the molecular structure of cell adhesion molecules, their binding sites, and adhesion complexes. For the cadherins, protein zero, and CD2, additional experimental data support the insights obtained from structural analysis of their domains and molecular models of their adhesion complexes. For neural cell adhesion molecules, L1, fibronectin, tenascin-C, integrins, and vascular cell adhesion molecules, the molecular structure of domains, and in most cases their binding sites, have been elucidated. The substrate recognition sites in some of these molecules possess rate constants for association and dissociation that permit both rapid cell migration and, through avidity, high-affinity cell-cell interactions.