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Neutrophil Function in Elderly Persons Assessed by Flow Cytometry

1996; Taylor & Francis; Volume: 25; Issue: 3 Linguagem: Inglês

10.3109/08820139609059301

1532-4311

B Esparza, Hugo Machado Sánchez, Margaret Ruiz, M. Barranquero, Éster Cerdeira Sabino, Fernando Merino,

Cell Adhesion Molecules Research

It is well known that the immune response declines with senescence and it is suggested that these changes render an individual susceptible to infection, autoimmune phenomena and cancer. Bacterial and viral infections are a major cause of illness and death amongst aged subjects, and once infection is established, the elderly also have a diminished capacity to prevent its spread (1). The cellular and molecular basis for this age-related decline in immuno-competence are still unknown and, possibly, are related to an alteration in cell transduction mechanisms (2).