Produção Nacional
Revisado por pares
Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes
2014; American Association for the Advancement of Science; Volume: 347; Issue: 6217 Linguagem: Inglês
10.1126/science.1258522
ISSN1095-9203
AutoresDaniel E. Neafsey, Robert M. Waterhouse, Mohammad Reza Abai, Sergey Aganezov, Max A. Alekseyev, James E. Allen, James Amon, Bruno Arcà, Peter Arensburger, Gleb N. Artemov, Lauren A. Assour, Hamidreza Basseri, Aaron Berlin, Bruce W. Birren, Stéphanie Blandin, Andrew I. Brockman, Thomas R. Burkot, Austin Burt, Clara S. Chan, Cédric Chauve, Joanna C. Chiu, Mikkel Christensen, Carlo Costantini, Victoria L M Davidson, Elena Deligianni, Tania Dottorini, Vicky Dritsou, Stacey B. Gabriel, Wamdaogo M. Guelbéogo, A. Brantley Hall, Mira V. Han, Thaung Hlaing, Daniel Hughes, Adam M. Jenkins, Xiaofang Jiang, Irwin Jungreis, Evdoxia G. Kakani, Maryam Kamali, Petri Kemppainen, Ryan Kennedy, Ioannis Kirmitzoglou, Lizette L. Koekemoer, Njoroge Laban, Nicholas Langridge, Mara Lawniczak, Manolis Lirakis, Neil F. Lobo, Ernesto Lowy, Robert M. MacCallum, Chunhong Mao, G. Maslen, Charles Mbogo, Jennifer B. McCarthy, Kristin Michel, Sara N. Mitchell, Wendy Moore, Katherine A. Murphy, Anastasia N. Naumenko, Tony Nolan, Eva Maria Novoa, Samantha M. O’Loughlin, Chioma Oringanje, Mohammad Ali Oshaghi, Nazzy Pakpour, Philippos Aris Papathanos, Ashley Peery, Michael Povelones, Anil Prakash, David P. Price, Ashok Rajaraman, Lisa J. Reimer, David C. Rinker, Antonis Rokas, Tanya L. Russell, N’Falé Sagnon, Maria V. Sharakhova, Terrance Shea, Felipe A. Simão, Frédéric Simard, Michel A. Slotman, Pradya Somboon, V. N. Stegniy, Cláudio J. Struchiner, Gregg W.C. Thomas, Marta Tojo, Pantelis Topalis, José M. C. Tubío, Maria Unger, John Vontas, Catherine Walton, Craig S. Wilding, Judith H. Willis, Yi-Chieh Wu, Guiyun Yan, Evgeny M. Zdobnov, Xiaofan Zhou, Flaminia Catteruccia, George K. Christophides, Frank H. Collins, Robert S. Cornman, Andrea Crisanti, Martin J. Donnelly, Scott Emrich, Michaël C. Fontaine, William M Gelbart, Matthew W. Hahn, Immo A. Hansen, Paul Howell, Fotis C. Kafatos, M. Kellis, Daniel Lawson, Christos Louis, Shirley Luckhart, Marc A. T. Muskavitch, José M. C. Ribeiro, Michael A. Riehle, Igor V. Sharakhov, Zhijian Tu, Laurence J. Zwiebel, Nora J. Besansky,
Tópico(s)Insect symbiosis and bacterial influences
ResumoVariation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.
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