Disintegration-Dissolution Analysis of Percent Dissolved-Time Data
1981; Elsevier BV; Volume: 70; Issue: 5 Linguagem: Inglês
10.1002/jps.2600700518
ISSN1520-6017
Autores Tópico(s)Surfactants and Colloidal Systems
ResumoA simple, graphical method is described for the disintegration--dissolution analysis of cumulative percent dissolved--time data. The technique is based on a biexponential equation with the assumption of first-order disintegration and dissolution according to a simple dissolution model. The dissolution data obtained for six commercial tablets and capsules adequately fit the developed equation. The described method is simple and can handle initial data points that are usually ignored by other techniques.
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