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Antioxidant protection against acoustic trauma by coadministration of idebenone and vitamin E

2008; Lippincott Williams & Wilkins; Volume: 19; Issue: 3 Linguagem: Inglês

10.1097/wnr.0b013e3282f50c66

1473-558X

Anna Rita Fetoni, Aldo Ferraresi, Carmelo La Greca, Davide Rizzo, Bruno Sergi, Giuseppe Tringali, Roberto Piacentini, Diana Troiani,

Olfactory and Sensory Function Studies

Idebenone, a synthetic analogue of coenzyme Q, attenuates noise-induced hearing loss by virtue of its antioxidant properties. This study involves a guinea pig model of acoustic trauma where the effectiveness of idebenone is analyzed in comparison with Vitamin E (α-tocopherol) that exhibits a potent antioxidant activity in the inner ear. Idebenone and vitamin E were injected intraperitoneally 1 h before noise exposure and once daily for three days; functional and morphological studies were then carried out, respectively, by auditory brainstem responses evaluation, scanning electron microscopy and terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay identification of missing and apoptotic cells was also performed. The results showed that the protective effects of idebenone and vitamin E were not additive implying that the two antioxidants may share competitive mechanisms.