Portal de Periódicos da CAPES

Formal Synthesis of (±)-Dendrobine: Use of the Amidofuran Cycloaddition/Rearrangement Sequence

2000; American Chemical Society; Volume: 2; Issue: 20 Linguagem: Inglês

10.1021/ol006444h

1523-7060

Albert Padwa, Martin Dimitroff, Bing Liu,

Cholinesterase and Neurodegenerative Diseases

The formal synthesis of the alkaloid (±)-dendrobine (4) was accomplished using the IMDAF cycloaddition/rearrangement sequence of a furanyl carbamate. Conversion of the rearranged cycloadduct to Kende's advanced intermediate in eight steps completed the formal synthesis of (±)-dendrobine.