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Synthesis of Optically Active Oxazoline Derivatives via Catalytic Asymmetric Desymmetrization of 1,3‐Diols

2012; Wiley; Volume: 18; Issue: 9 Linguagem: Inglês

10.1002/chem.201103800

1521-3765

Yutaro Tsuda, Masami Kuriyama, Osamu Onomura,

Catalytic C–H Functionalization Methods

Chiral oxazolines: A synthetic method to prepare optically active oxazolines through a copper-catalyzed asymmetric desymmetrization of 1,3-diols has been successfully developed. This reaction system tolerated a diverse range of substrates to give the desired oxazoline derivatives in good to excellent yields with high enantioselectivities (see scheme). Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.