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In vitro activities of trimethoprim and sulfamethoxazole against Listeria monocytogenes

1982; American Society for Microbiology; Volume: 22; Issue: 1 Linguagem: Inglês

10.1128/aac.22.1.51

1098-6596

Dean L. Winslow, GA Pankey,

Phenothiazines and Benzothiazines Synthesis and Activities

The in vitro activities of trimethoprim and sulfamethoxyazole against clinical isolates of Listeria monocytogenes were examined separately and in combination with a microtiter broth dilution system. Sulfamethoxazole demonstrated variable activity and was generally bacteriostatic. Trimethoprim alone was bactericidal against 96% of isolates at less than 0.5 microgram/ml. The bactericidal action of trimethoprim against L. monocytogenes was generally potentiated by sulfamethoxyazole even when isolates were relatively resistant to sulfamethoxyazole alone.