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Enantioselective synthesis and application of the highly fluorescent and environment-sensitive amino acid 6-(2-dimethylaminonaphthoyl) alanine (DANA)Electronic supplementary information (ESI) available: experimental details. See http://www.rsc.org/suppdata/cc/b2/b205224e/

2002; Royal Society of Chemistry; Issue: 17 Linguagem: Inglês

10.1039/b205224e

1364-548X

Mark Nitz, Adam R. Mezo, Mayssam H. Ali, Barbara Imperiali,

Chemical Synthesis and Analysis

6-(2-Dimethylaminonaphthoyl) alanine (DANA) was prepared via an enantioselective synthesis and incorporated into the S-peptide of RNase S establishing the large changes in fluorescence that can occur upon peptide–protein interaction.