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Zn(ii) ions bind very efficiently to tandem repeat region of “prion related protein” (PrP-rel-2) of zebra-fish. MS and potentiometric evidence

2008; Royal Society of Chemistry; Issue: 44 Linguagem: Inglês

10.1039/b811224j

1477-9234

Łukasz Szyrwiel, Elżbieta Jankowska, Anna Janicka-Kłos, Zbigniew Szewczuk, Daniela Valensin, Henryk Kozłowski,

Drug Transport and Resistance Mechanisms

Multi-histidine peptide fragments of zebra-fish prion protein are effective ligands for Zn(II) ions. Moreover the formation of a dinuclear complex species with a longer peptide can suggest the existence of the cooperative effect in the metal ion binding.